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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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New technique enhances quality control of lab-grown cells for AMD treatment

NEI researchers improved a crucial step in the production of retinal pigment epithelium (RPE), a tissue they grow in the lab from patient blood cells and are testing in a clinical trial as treatment for AMD.

LSU Health discovery may open new therapeutic avenues for degenerative diseases of the brain and eye

Researchers at Louisiana State University have identified a new mechanism that protects against the excessive oxidative stress that precedes the development of neurodegenerative diseases of the brain and eye.

NEI study shows how genes in retina get regulated during development

Researchers at the National Eye Institute have mapped the 3D organization of genetic material of key developmental stages of human retinal formation, using intricate models of a retina grown in the lab.

Story of discovery: NEI-funded research paves way for new dry AMD drugs

This year, the Food and Drug Administration (FDA) approved Syfovre (pegcetacoplan) and Izervay (avacincaptad pegol), the very first drugs for treating geographic atrophy (GA), also known as late-stage “dry” age-related macular degeneration (AMD).
Artistic rendering of a retinal organoid.

Johns Hopkins Medicine scientists uncover molecular link between wet and dry macular degeneration

Wilmer Eye Institute researchers at Johns Hopkins Medicine have found how oxidative stress and the protein HIF-1 contributes to what kind of age-related macular degeneration (AMD) a patient could develop.

Signs of glaucoma may be detectable years in advance of disease onset

Research funded by the National Eye Institute suggests that low density of pigment in the macula, the region of the retina required for sharp central vision, is associated with thinning of the retina and may serve as an early warning sign of glaucoma.
Andrew Bower

NEI postdoc to use research award to study cellular function with adaptive optics

The K99/R00 provides a runway for postdocs seeking to transition from mentored positions to tenure track positions at academic institutions in the U.S.

Stanford Medicine researchers build an eye ‘aging clock’ that could lead to treatments for ocular diseases

Using a technique they developed for studying eye fluid, Stanford Medicine researchers and their collaborators have found a way to measure ocular aging, opening avenues for treatment of numerous eye diseases.

NEI grantees receive Lasker Award for imaging discovery

The Lasker Foundation cited a trio of scientists, who with NEI funding, developed OCT, one of the most widely used technologies for imaging the eye.
Fundus photo showing medium drusen

LSU Health New Orleans researchers discover a key failure in AMD that may lead to progression and vision loss

Research suggests that age-related macular degeneration (AMD) decreases an essential fatty acid, preventing the formation of a class of protective molecules and reducing repair potential.

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