Scientists reveal new target for anti-lymphangiogenesis drugs

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Emerging field of study yields new hope for organ transplant rejection, cancer metastasis, and lymphedema

April 12, 2016

Corneal Conditions Immunology Infectious Disease

Basic Research

Grantee

After an injury to tissues, such as in organ transplantation, the body grows new lymphatic vessels in a process known as lymphangiogenesis. A new study in Nature Communications reveals a mechanism involved in the regulation of this process, specifically in corneal transplants and infectious eye disease. The team, led by researchers from Tufts University School of Medicine, the Sackler School of Graduate Biomedical Sciences at Tufts, and Tufts Medical Center, successfully prevented corneal inflammation, a condition that adversely affects transplantation, by inhibiting the overgrowth of these lymphatic vessels in a mouse animal model.